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Daniel M Aebersold Selected Research

Proto-Oncogene Proteins c-met

1/2020Targeting the MET Receptor Tyrosine Kinase as a Strategy for Radiosensitization in Locoregionally Advanced Head and Neck Squamous Cell Carcinoma.
1/2018Identification of a MET-eIF4G1 translational regulation axis that controls HIF-1α levels under hypoxia.
11/2016Depletion of FOXM1 via MET Targeting Underlies Establishment of a DNA Damage-Induced Senescence Program in Gastric Cancer.
8/2015KRAS and HRAS mutations confer resistance to MET targeting in preclinical models of MET-expressing tumor cells.
7/2015Impact of MET targeting on tumor-associated angiogenesis and growth of MET mutations-driven models of liver cancer.
3/2014Targeting of the MET receptor tyrosine kinase by small molecule inhibitors leads to MET accumulation by impairing the receptor downregulation.
2/2013Protective autophagy is involved in resistance towards MET inhibitors in human gastric adenocarcinoma cells.
2/2012MET inhibition in tumor cells by PHA665752 impairs homologous recombination repair of DNA double strand breaks.
11/2003Prevalence and clinical impact of Met Y1253D-activating point mutation in radiotherapy-treated squamous cell cancer of the oropharynx.

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Daniel M Aebersold Research Topics

Disease

50Neoplasms (Cancer)
07/2022 - 06/2002
31Prostatic Neoplasms (Prostate Cancer)
01/2022 - 06/2004
17Squamous Cell Carcinoma of Head and Neck
11/2021 - 01/2009
13Neoplasm Metastasis (Metastasis)
02/2022 - 11/2003
12Head and Neck Neoplasms (Head and Neck Cancer)
07/2022 - 03/2010
4Hypoxia (Hypoxemia)
11/2020 - 06/2003
4Uterine Cervical Neoplasms (Cancer of the Cervix)
12/2017 - 06/2003
3Breast Neoplasms (Breast Cancer)
09/2019 - 07/2002
3Hepatocellular Carcinoma (Hepatoma)
01/2017 - 02/2009
2Genomic Instability
11/2020 - 01/2020
2Second Primary Neoplasms (Neoplasms, Second)
06/2019 - 12/2015
2Squamous Cell Carcinoma (Epidermoid Carcinoma)
01/2019 - 07/2012
2Malignant Mesothelioma
01/2019 - 12/2015
2Non-Small-Cell Lung Carcinoma (Carcinoma, Non-Small Cell Lung)
11/2018 - 05/2011
2Margins of Excision
01/2018 - 07/2012
2Pterygium
05/2017 - 12/2009
2Carcinogenesis
01/2017 - 02/2013
2Pneumonia (Pneumonitis)
12/2015 - 05/2011
2Adenocarcinoma
02/2013 - 06/2003
1AIDS-Related Complex (ARC)
07/2022
1Fibrosis (Cirrhosis)
07/2022
1Liver Cirrhosis (Hepatic Cirrhosis)
07/2022
1Pain (Aches)
02/2022
1Brain Neoplasms (Brain Tumor)
10/2021
1Reperfusion Injury
01/2021
1Hepatitis
01/2021
1Ischemia
01/2021
1Gynecomastia
07/2020
1Mastodynia
07/2020
1Small Cell Lung Carcinoma (Small Cell Lung Cancer)
01/2020
1Lung Neoplasms (Lung Cancer)
09/2019
1Germ Cell and Embryonal Neoplasms (Germ Cell Tumor)
02/2019
1Mesothelioma
01/2019
1Laryngeal Neoplasms (Laryngeal Cancer)
01/2019
1Lymphatic Metastasis
12/2018
1Astigmatism
05/2017
1Glioblastoma (Glioblastoma Multiforme)
01/2017

Drug/Important Bio-Agent (IBA)

9Proto-Oncogene Proteins c-metIBA
01/2020 - 11/2003
7Cisplatin (Platino)FDA LinkGeneric
12/2017 - 05/2011
5Proteins (Proteins, Gene)FDA Link
01/2020 - 06/2002
5Receptor Protein-Tyrosine Kinases (Tyrosine Kinase Receptors)IBA
05/2015 - 07/2008
4AndrogensIBA
01/2021 - 01/2017
4DNA (Deoxyribonucleic Acid)IBA
11/2020 - 02/2012
4Biological ProductsIBA
11/2020 - 07/2015
3Hormones (Hormone)IBA
01/2022 - 12/2019
3Protein-Tyrosine Kinases (Tyrosine Kinase)IBA
01/2020 - 01/2018
3Phosphotransferases (Kinase)IBA
02/2017 - 12/2013
3EMD1214063IBA
08/2015 - 02/2013
2Fluorodeoxyglucose F18 (Fludeoxyglucose F 18)FDA Link
11/2021 - 03/2014
2ElementsIBA
11/2020 - 05/2017
2Growth Factor ReceptorsIBA
01/2020 - 12/2013
2Protons (Proton)IBA
02/2019 - 04/2009
2MicroRNAs (MicroRNA)IBA
01/2018 - 01/2017
2Hepatocyte Growth Factor (Growth Factor, Hepatocyte)IBA
01/2018 - 11/2003
2Biomarkers (Surrogate Marker)IBA
01/2018 - 11/2016
2StrontiumIBA
05/2017 - 12/2009
2tyrosine receptor (receptor, tyrosine)IBA
02/2017 - 05/2015
2LigandsIBA
05/2015 - 08/2009
25- ((2,6- dichlorobenzyl)sulfonyl)- 3- ((3,5- dimethyl- 4- ((2- (pyrrolidin- 1- ylmethyl)pyrrolidin- 1- yl)carbonyl)- 1H- pyrrol- 2- yl)methylene)- 1,3- dihydro- 2H- indol- 2- oneIBA
02/2013 - 02/2012
2GoldIBA
11/2009 - 04/2006
1Reactive Oxygen Species (Oxygen Radicals)IBA
07/2022
1RNA (Ribonucleic Acid)IBA
07/2022
1Mitochondrial DNA (mtDNA)IBA
07/2022
1CBLB502IBA
01/2021
1Interleukin-22 (IL-22)IBA
01/2021
1Tumor Biomarkers (Tumor Markers)IBA
01/2021
1Concanavalin AIBA
01/2021
1HoloenzymesIBA
11/2020
1Cytoplasmic and Nuclear Receptors (Nuclear Receptors)IBA
11/2020
1Anastrozole (Arimidex)FDA LinkGeneric
07/2020
1Androgen Antagonists (Antiandrogens)IBA
07/2020
1Abiraterone AcetateIBA
12/2019
1abirateroneIBA
12/2019
1PlatinumIBA
06/2019
1Cetuximab (Erbitux)FDA Link
06/2019
1Amino AcidsFDA Link
01/2018
1LipidsIBA
01/2018
1Tyrosine Kinase InhibitorsIBA
01/2018
1Mitogen-Activated Protein KinasesIBA
01/2018
1GemcitabineFDA Link
12/2017
1Forkhead Box Protein M1IBA
11/2016

Therapy/Procedure

61Radiotherapy
07/2022 - 06/2002
18Therapeutics
07/2022 - 10/2012
10Brachytherapy
05/2014 - 06/2003
8Prostatectomy (Retropubic Prostatectomy)
01/2022 - 04/2012
8Intensity-Modulated Radiotherapy (Radiotherapy, Intensity Modulated)
02/2019 - 04/2006
7Drug Therapy (Chemotherapy)
01/2021 - 01/2009
3Neck Dissection (Radical Neck Dissection)
02/2016 - 03/2010
2Palliative Care (Palliative Therapy)
01/2021 - 07/2003
2Aftercare (After-Treatment)
06/2019 - 08/2012
2Pneumonectomy (Lung Volume Reduction)
01/2019 - 12/2015
2Chemoradiotherapy
08/2016 - 01/2016
2Lasers (Laser)
01/2015 - 01/2010
1Gastrostomy
12/2020
1Off-Label Use
07/2020
1Cranial Irradiation
01/2020
1Duration of Therapy
09/2019
1Immunotherapy
09/2019
1Segmental Mastectomy (Lumpectomy)
09/2019
1Adjuvant Radiotherapy
01/2019